The dog model of left ventricular remodeling after myocardial infarction.

BACKGROUND For over a century, the dog model has been used widely in research studying cardiovascular physiology pertinent to humans. It has been specially applied, over the past 2 decades, in research on the pathophysiology and treatment of left ventricular (LV) remodeling and heart failure. METHODS AND RESULTS Because progressive LV remodeling and the march to heart failure are major problems facing myocardial infarction (MI) survivors, the dog model of acute MI was modified for the study of LV structural remodeling and dysfunction during post-MI healing (especially anterior MI). The dog model of post-MI LV remodeling, as the other models, has contributed to our understanding of the pathophysiology of LV remodeling and underlying mechanisms, and to the development of improved therapeutic strategies. Recent increase in costs and public concern over their use in research should be considered when using this model. CONCLUSIONS This is an important model for studying strategies to prevent severe LV remodeling in humans.